منابع مشابه
Thymus-dependent lymphocytes in human bone marrow.
Human bone marrow is known to contain significant numbers of bursa-dependent lymphocytes. The presence of thymus-dependent (T) cells is controversial. Bone marrow cells obtained from healthy volunteers was fractionated by density centrifugation. A lymphocte-enriched subpopulation was shown to be reactive to alloantigens in mixed lymphocyte culture and to contain substantial numbers of T lymphoc...
متن کاملPreliminary characterization of two thymus-dependent xenoantigens from mouse lymphocytes.
Preliminary characterization of two mouse thymus-dependent (T) lymphocyte xenoantigens, T25 and T200, which are selectively labelled by lactoperoxidase-catalysed iodination of T-cells, is described. Both molecules are membrane-bound glycoproteins. Fractionation of membrane vesicles prepared from BW5147 lymphoma cells by sedimentation through sucrose density gradients show that antigens T25 and ...
متن کاملCharacterization of Thymus-derived Lymphocytes
To characterize the function of the CD3r1 subunit of the T cell receptor (TCR), we have used cDNAs encoding CD3', CD3r1, or both to reconstitute a variant o£ a cytochrome c-specific, I-Ek-restricted murine T cell hybridoma, termed MA5.8, which lacks CD3' and CD3r1 proteins. We provide direct evidence that assembly and surface expression of TCRs can be mediated by either of these subunits separa...
متن کاملThymus-dependent Lymphocytes in Tissue Sections of Rejecting Rat Renal Allografts
Lewis kidneys were grafted into BN recipients and examined at daily intervals up to 6 days after grafting with immunofluorescent reagents. A horse antiserum specific for T lymphocytes revealed an increasing number of T lymphocytes in the cellular infiltrates of rejecting allografts. These were detectable 1 day after grafting, reached a maximum 3 days later, and were relatively diminished at 6 d...
متن کاملDeficit of Specific Thymus-dependent Lymphocytes in Transplantation Tolerance in the Rat
Recovery from adoptively terminated transplantation tolerance was studied by utilizing formerly tolerant rats as donors of lymphocytes in local renal graft-vs.-host reactions (GVHR). The origin of the proliferating lymphocytes in the GVHR was studied by means of sex chromosome markers. A deficit of specifically reactive lymphocytes, while tolerance was in effect, was revealed by the continuing ...
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ژورنال
عنوان ژورنال: Nature
سال: 1975
ISSN: 0028-0836,1476-4687
DOI: 10.1038/258106a0